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KMID : 1094020150320060544
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Journal of Veterinary Clinics
2015 Volume.32 No. 6 p.544 ~ p.547
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Glioblastoma in a Pekingese
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Cho Hyun-Kee
Kang Joo-Yeon
Chung Jin-Young
Yoo Dae-Young
Hwang In-Koo
Lee Kwon-Young
Choi Jung-Hoon
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Abstract
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An 11-year-old, intact male Pekingese was brought to the Veterinary Teaching Hospital of Kangwon NationalUniversity with a 10-day history of seizures. Fifteen days before coming to Kangwon National University, the doghad visited a local animal hospital for lameness, and non-steroidal anti-inflammatory drugs were prescribed to treatthis symptom. However, 10 days before coming to our hospital, the dog experienced generalized seizures. Two daysbefore his arrival, generalized ataxia and mental dullness also occurred. Our examinations revealed no remarkablefindings on a routine blood test or X-ray. However, the neurological examinations confirmed mental dullness, generalizedataxia, and a lack of menace response and pupillary light reflexes. Nine hours later, dyspnea occurred, and 12 hoursafter that, the patient was euthanized per the client’s request. A necropsy of transverse sections confirmed the presenceof a prominent midline shift due to extended tumor growth. On histopathological analyses, pseudopalisading necrosisof the glial cells and microvascular proliferation were observed. In immunohistochemical analysis, glial fibrillary acidicprotein, proliferating cell nuclear antigens, and ionized calcium binding adaptor molecule 1 immunoreactive cells wereobserved in the tumor area. Based on the results, the tumor was confirmed to be a glioblastoma. Primary intracranialtumors are rare in the veterinary field. This case report describes the clinical and histopathological findings ofglioblastoma in a Pekingese.
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KEYWORD
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brain tumor, dog, glioblastoma
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